Pathogenesis of Endotoxic Shock Transglutaminase Type II Is Involved in the
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Are NKT cells essential for endotoxic shock?
Endotoxic shock is a major health threat caused by gram-negative bacteria and their unique cell wall component, lipopolysaccharide, which induces exaggerated production of proinflammatory cytokines. Although macrophages play a central role in the pathogenesis of endotoxic shock, natural killer (NK)1+ cells are also involved in this mechanism. NK1+ cells comprise two major populations, namely NK...
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Progranulin (PGRN) is a crucial secreted growth factor involved in various kinds of physiologic and disease processes and often has a protective role in inflammatory diseases. This study was designed to investigate the protective effects of PGRN on endotoxic shock in a mouse model of PGRN deficiency. After lipopolysaccharide (LPS) injection to induce endotoxic shock in mice, PGRN levels were in...
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This study was conducted to determine the effects of prophylactic supplementation of vitamin E and Se on oxidative damage and antioxidant status. Fifteen healthy male buffalo (Bubalus bubalis) calves between the age of 6 to12 months were divided into three groups of five animals each: Group I-control, group II-endotoxic shock group infused with lyophilized E coli endotoxin @ 5 μg/kg body wt, an...
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Free radicals and proinflammatory cytokines from phagocytes have been implicated in the pathogenesis of endotoxic shock, a disease with high mortality caused by Gram-negative bacterial endotoxin. In the present study, male BALB/c and Swiss mice received intraperitoneally lipopolysaccharide (LPS) at 100 mg/kg and 150 mg/kg, respectively, that led to a lethal endotoxic shock (100 % of mortality b...
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